MOTS-C
From $119
MOTS-C — Research Compound MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA Type-C) is a 16-amino acid mitochondrial-derived peptide encoded within the mitochondrial 12S rRNA gene. It represents a novel mechanism of mitochondrial- nuclear communication, linking cellular energy status to gene expression
Mechanism of Action- Activates the AMPK pathway via inhibition of the folate-AICAR cycle. - Translocates to the nucleus under metabolic stress to regulate gene expression through NRF2 binding. - Targets skeletal muscle, liver, and adipose tissue with high tissue specificity. - Restores metabolic flexibility and enhances mitochondrial function.
Pharmacokinetics- Excellent subcutaneous bioavailability. - Age-related plasma decline noted, suggesting therapeutic potential in aging and metabolic disorders. - Investigational analog: CB4211, under study for hepatic steatosis.
Specifications:
Compound: MOTS-C
Format: Research compound
Use: Research use only
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Certificate of Analysis
Third Party Tested · ISO/IEC 17025 Accredited
7×
Testing
Passed full QC panel
- Variant
- MOTS-C 10mg
- Lot #
- 4955
- Category
- Research Compounds
- Tested
- Oct 19, 2026
ISO/IEC 17025 Accredited
View COACompound Information
Technical specifications
What is MOTS-C?
- Type
- Synthetic compound
- Category
- Research Compounds
- Form
- Lyophilized powder
- Lot
- 4955
Important Research Notice
Not for human consumption. This product is sold exclusively as a research reagent for in vitro and laboratory use by qualified researchers. It is not a drug, supplement, or cosmetic, is not intended for human or veterinary use, and is not intended to diagnose, treat, cure, or prevent any disease. No dosing, administration, or benefit claims are made or implied.
Published literature referenced on this page describes third-party studies of the compound class and is provided for scientific context only. It is not a claim about this product and not evidence of safety or efficacy in any organism.
By purchasing this product, you confirm that you are a qualified researcher and will use it in accordance with all applicable laws and regulations.
